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. 2017 Jan 27;312(4):R597–R610. doi: 10.1152/ajpregu.00433.2016

Fig. 11.

Fig. 11.

Oral stimulation with drugs known to either increase (glyburide) or decrease (diazoxide) KATP channel activity produced corresponding changes in CPIR magnitude (experiment 8). Each test involved two sessions: one was conducted with a control solution and the other with an experimental solution. A: in the glyburide test, the control solution was 0.5 M glucose (Glu) and the experimental solution was 0.5 M glucose + 0.15 mM glyburide (GB). B: in the diazoxide test, the control solution was 1 M glucose and the experimental solution was 1 M glucose + 0.25 mM diazoxide (DZ). Within a given panel, we represent the results from each mouse as two points connected by a line. The Δ plasma insulin concentration reflects the change in plasma insulin concentration between measurements obtained at baseline and 5 min after a mouse initiated licking for the experimental or control solution. Within each panel, we compare the Δ plasma insulin concentration elicited by the control vs. experimental solutions (paired t-test, *P < 0.03).