Fig. 6.

Longitudinal changes in fibrosis burden observed with MRI. During fibrosis progression, percent high signal intensity volume increased significantly at a rate of 1.5% per week (A) and mean weighted signal (C) increased significantly at 0.0065 wk⁻¹, whereas the signal coefficient of variation (E) decreases significantly at −0.13 wk⁻¹. During fibrosis resolution, CV (F) did not change significantly, whereas percent high signal intensity volume (B) decreased significantly at −3.2% wk⁻¹ and mean weighted signal (D) decreased significantly at −0.011 wk⁻¹.