Table 3.
Pharmacokinetic Parameters of Etravirine*
| Etravirine PK Parameter | Darunavir/Ritonavir Plus Etravirine (Group 2) |
|
|---|---|---|
| Etravirine 200 mg Twice-Daily (Group 2A) | Etravirine 400 mg Once-Daily (Group 2B) | |
| N | 6 | 9 |
| AUC target range (mg × h/L) | 4.4–6.9 | 8.3–13.0 |
| AUC24 (mg × h/L) | 8.6 (4.4–16.8)† | 11.9 (7.5–18.9) |
| C24 (mg/L) | 0.3 (0.1–0.7) | 0.3 (0.2–0.5) |
| Cmax (mg/L) | 0.5 (0.3–0.9) | 0.9 (0.7–1.3) |
| T1/2 (h) | 25.1 (12.1–51.8) | 17.9 (11.0–29.1) |
| CL/F (L/h) | 46.4 (23.8–90.5) | 33.5 (21.2–53.1) |
| V/F (L) | 1677 (747.8–3760) | 863.5 (566.4–1316) |
Abbreviations: AUC, are under the curve; CI, confidence interval; C24, plasma concentration at 24 hours; CL/F, oral clearance; Cmax, maximum plasma concentration; pharmacokinetics; T1/2, half-life; V/F, volume of distribution.
*Values presented as geometric mean (90% CI geometric mean).
†AUC12 × 2.