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Identification of estrogen-related receptor-β (ESRRβ) in cardiac metabolism. A: schematic of high-throughput qPCR screen. B: fold expression of upregulated genes in skeletal muscle of MCK-PGC-1Tg compared with control littermates. C: relative ESRRβ mRNA expression in various tissues. D: relative ESRRβ mRNA expression in heart, skeletal muscle, and kidney of MHC-ERRBKO and control mice at 2 mo. Data are presented as means ± SE; n = 4–6 per group; *P < 0.05 compared with control animals.
