Table 2.
Associations with mean telomere length in NHANES participants that were FDR < 5%
| Description | Category | Estimate | 95% CI | P | FDR | Adjusted R2 (full- reduced model) |
|---|---|---|---|---|---|---|
| PCB138 (1 SD of log) | PCBS | 0.169 | [0.105, 0.234] | 9.7 × 10−5 | 0.015 | 0.0092 |
| Cadmium (1 SD of log) | Heavy metals | −0.063 | [−0.088, −0.039] | 1.2 × 10−4 | 0.015 | 0.0039 |
| PCB99 (1 SD of log) | PCBS | 0.156 | [0.092, 0.220] | 2.1 × 104 | 0.015 | 0.0122 |
| PCB170 (1 SD of log) | PCBS | 0.140 | [0.082, 0.197] | 2.1 × 10−4 | 0.015 | 0.0074 |
| 3,3′,4,4′,5,5′-HXCB (1 SD of log) | PCBS | 0.171 | [0.100, 0.242] | 2.3 × 10−4 | 0.015 | 0.0114 |
| Trunk fat (1SD) | Body measures | −0.075 | [−0.106, −0.044] | 2.3 × 10−4 | 0.015 | 0.0053 |
| PCB156 (1 SD of log) | PCBS | 0.122 | [0.071, 0.174] | 2.6 × 10−4 | 0.015 | 0.0073 |
| PCB153 (1 SD of log) | PCBS | 0.178 | [0.103, 0.253] | 2.7 × 10−4 | 0.015 | 0.0081 |
| PCB146 (1 SD of log) | PCBS | 0.114 | [0.065, 0.163] | 3.2 × 10−4 | 0.015 | 0.0037 |
| PCB180 (1 SD of log) | PCBS | 0.165 | [0.094, 0.236] | 3.4 × 10−4 | 0.015 | 0.0068 |
| PCB74 (1 SD of log) | PCBS | 0.192 | [0.108, 0.276] | 3.8 × 10−4 | 0.016 | 0.0164 |
| PCB187 (1 SD of log) | PCBS | 0.135 | [0.074, 0.196] | 4.9 × 10−4 | 0.018 | 0.0057 |
| Alkaline phosphatase (1 SD of log) | Biochemistry | −0.068 | [−0.099, −0.037] | 5.1 × 104 | 0.018 | 0.0040 |
| C-reactive protein (1 SD of log) | Biochemistry | −0.080 | [−0.118, −0.043] | 6.4 × 10−4 | 0.021 | 0.0042 |
| Average cigarettes/day during past 30 days (1 SD) | Smoking behaviour | −0.100 | [−0.148, −0.052] | 8.3 × 10−4 | 0.024 | 0.0081 |
| Cadmium, urine (1 SD of log) | Heavy metals | −0.078 | [−0.115, −0.040] | 8.4 × 10−4 | 0.024 | 0.0379 |
| PCB118 (1 SD of log) | PCBS | 0.161 | [0.080, 0.243] | 1.3 × 10−3 | 0.035 | 0.0108 |
| Predicted VO2max (1 SD) | Physical fitness | 0.134 | [0.066, 0.202] | 1.4 × 10−3 | 0.036 | 0.0078 |
| Retinyl stearate (1 SD of log) | Nutrients | 0.045 | [0.022, 0.067] | 1.5 × 10−3 | 0.036 | 0.0016 |
| 60-s pulse (1SD) | Blood pressure | −0.051 | [−0.078, −0.024] | 1.9 × 10−3 | 0.044 | 0.0018 |
| 3,3′,4,4′,5-PNCB (1 SD of log) | PCBS | 0.110 | [0.051, 0.168] | 2.0 × 10−3 | 0.045 | 0.0083 |
| Lumbar pelvis BMD (1 SD) | Body measures | −0.059 | [−0.091, −0.027] | 2.4 × 10−3 | 0.050 | 0.0024 |
Last column is the additional variance explained (R2) for the variable. Estimates are to be interpreted as 1 SD unit change in telomere length for a 1 SD unit change in environmental, behavioural or clinical variable.