Fig. 6.

Accelerated deflation promotes reaeration in local edema model. A: example images of local edema model regions ventilated with PEEP of 15 cmH₂O and V_T of 6 ml/kg without or with accelerated deflation. Fluorescein-labeled albumin solution fills flooded alveoli and lines perimeters of aerated alveoli. Air and alveolar septal tissue are black. B: group alveolar flooding data for same conditions as in A. C: data from final time point of B reported in alternative percentage reaerated format. D: effects of ventilation settings and accelerated deflation on percentage reaerated. P_AW⋅MAX is maximal airway pressure in the isolated lungs. Peak inspiratory pressure (PIP) is an estimate of the equivalent maximal airway pressure in a closed-chest preparation (14, 24). *P < 0.05 vs. passive deflation with same PEEP and V_T; #P < 0.05 vs. PEEP of 5 cmH₂O with same V_T and deflation type; ○P < 0.05 vs. V_T of 6 ml/kg with same PEEP and deflation type.