Table 2.
Clinical Presentation and Outcomes of Patients With emm89 and emm1 iGAS Infections in Metropolitan Toronto, 2000–2014
| Clinical Presentation/Outcome | Clade O No. (%) |
Clade 1 No. (%) |
Clade 2 No. (%) |
Clade 3 No. (%) |
emm89 Total No. (%) | emm1 No. (%) |
|---|---|---|---|---|---|---|
| Total | 15 (100) | 18 (100) | 12 (100) | 60 (100) | 105 (100) | 397 (100) |
| Arthritis | 2 (13) | 4 (22) | 2 (17) | 9 (15) | 17 (16) | 32 (8)c |
| Bacteremia without focus | 0 (0) | 3 (17) | 3 (25) | 7 (12) | 13 (12) | 61 (15) |
| Soft Tissue Infection | ||||||
| Necrotizing fasciitis | 0 (0) | 0 (0) | 0 (0) | 2 (3) | 2 (2) | 36 (9)c |
| Other soft tissue | 10 (67) | 4 (22) | 1 (8) | 20 (33) | 35 (33) | 138 (35) |
| Respiratory Tract Infection | ||||||
| Lower respiratory | 2 (13) | 3 (17) | 5 (42) | 8 (13) | 18 (17) | 79 (20) |
| Upper respiratory | 1 (6) | 1 (6) | 1 (8) | 7 (12) | 10 (9) | 20 (5) |
| Peripartum infection | 0 (0) | 1 (6) | 0 (0) | 4 (7) | 5 (5) | 8 (2) |
| Othera | 0 (0) | 2 (11) | 0 (0) | 3 (5) | 5 (5) | 23 (6) |
| STSS | 1 (7) | 5 (28) | 5 (42) | 14 (23) | 25 (24) | 117 (29) |
| Case fatalityb | 1 (7) | 4 (22) | 5 (42) | 10 (17) | 20 (19) | 81 (20) |
| ICU admission | 4 (27) | 6 (33) | 5 (42) | 16 (27) | 31 (30) | 158 (40) |
Abbreviations: ICU, intensive care unit; iGAS, invasive group A Streptococcus; STSS, streptococcal toxic shock syndrome.
aOther includes peritoneal infection, gynecological infection not associated with pregnancy.
bCase fatality was defined as death that could be attributed to GAS infection within 30 days of positive culture.
c P < .05 for the comparison with all emm89 patients.