Table 2.

	FOLFIRINOX (n=6)				FOLFIRINOX plus PF-04136309 (n=39)
	Grade 1 or 2	Grade 3	Grade 4	Grade 5	Grade 1 or 2	Grade 3	Grade 4	Grade 5
Hematologic
Neutropenia	0	2 (33%)	4 (67%)	0	2 (5%)	15 (38%)	12 (31%)	0
Febrile neutropenia	0	0	1 (17%)	0	0	5 (13%)	2 (5%)	0
Anemia	4 (67%)	2 (33%)	0	0	34 (87%)	3 (8%)	0	0
Lymphopenia	2 (33%)	1 (17%)	0	0	20 (51%)	4 (10%)	0	0
Thrombocytopenia	4 (67%)	0	0	0	19 (49%)	1 (3%)	1 (3%)	0
Non-Hematologic
Nausea	3 (50%)	0	0	0	23 (59%)	1 (3%)	0	0
Vomiting	2 (33%)	0	0	0	13 (33%)	1 (3%)	0	0
Diarrhea	4 (67%)	2 (33%)	0	0	19 (49%)	6 (15%)	0	0
Mucositis	3 (50%)	0	0	0	16 (41%)	1 (3%)	0	0
Alopecia	4 (67%)	0	0	0	28 (72%)	0	0	0
Peripheral neuropathy	1 (17%)	0	0	0	25 (64%)	0	0	0
Hypoalbuminemia	4 (67%)	1 (17%)	0	0	25 (64%)	2 (5%)	0	0
Hypokalemia	1 (17%)	3 (50%)	0	0	17 (44%)	5 (13%)	2 (5%)	0
ELEVATED ASPARTATE Aminotransferase	2 (33%)	0	0	0	12 (31%)	2 (5%)	0	0