Table 1.
Summary of the known roles of nuclear hormone receptor signaling in tissue-resident stem cells
| Receptor | Ligand | Stem Cell | Role | References |
|---|---|---|---|---|
| Drosophila | ||||
| EcR | ecdysone | ovarian germline stem cell | directly and indirectly promotes proliferation and maintenance; indirectly promotes differentiation of daughters | [38, 39, 23, 40, 41] |
| EcR | ecdysone | testes cyst stem cell | promotes proliferation and maintenance; indirectly promotes maintenance of germline stem cells | [50] |
| EcR | ecdysone | larval neuroblast | promotes cell cycle exit and terminal differentiation | [74] |
| Mouse | ||||
| PR | progesterone | mammary stem cell | directly promotes proliferation and maintenance | [55, 56] |
| ER | estrogen | mammary stem cell | indirectly promotes proliferation and maintenance | [55, 56] |
| ERα | estrogen | hematopoietic stem cell | directly promotes proliferation and maintenance | [52] |
| TR | thyroid hormone | hair follicle stem cell | indirectly promotes proliferation, migration out of the niche | [93] |
| PPARδ | fatty acids | intestinal stem cell | directly promotes proliferation and maintenance in response to dietary fatty acids | [62] |
| Nurr1 | none | hematopoietic stem cell | directly represses proliferation/promotes quiescence | [94] |
| TLX | unknown | neural stem cell | directly promotes proliferation and maintenance | [95] |
| VDR | vitamin D | neural stem cell | directly promotes proliferation and survival; promotes differentiation of daughter cells to terminal fates | [96] |
| RAR | retinoic acid | hematopoietic stem cell | indirectly promotes differentiation | [97, 98] |