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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Shock. 2017 May;47(5):606–614. doi: 10.1097/SHK.0000000000000800

Figure 3. Cytokine Responses Following Overnight Incubation with Lipopolysaccharide.

Figure 3

In response to overnight whole-blood stimulation with lipopolysaccharide (LPS), healthy control (HC) significantly upregulated IFNƔ (p<0.01), IL-12 (p<0.01), MIP-1α (p<0.0001), TNFα (p<0.005), IP-10 (p<0.0001) while umbilical cord blood (UCB) had attenuated non-significant responses. IL-1β and IL-6 concentrations were significantly increased by both HC (p<0.005; p<0.01) and UCB (p<0.05; p<0.001). UCB had a significant increase in IL-10 (p<0.0001), while HC showed an attenuated non-significant increase. UCB also had a trend towards greater increase in MCP-1 post-LPS stimulation (p<0.0001) when compared to HC (p<0.01).