TABLE 1.
Count (%) |
||||
---|---|---|---|---|
Cardiac Lesion* | Cohort 1 | Cohort 2 | ||
Tetralogy of Fallot | 249 (39.7) | 118 (34.1) | ||
Pulmonary Stenosis | 195 (78.3) | 79 (66.9) | ||
Pulmonary Atresia | 41 (16.5) | 27 (22.9) | ||
Absent Pulmonary Valve | 6 (2.4) | 1 (0.8) | ||
Unspecified Pulmonary Anatomy | 7 (2.8) | 11 (9.3) | ||
Ventricular Septal Defect† | 120 (19.1) | 93 (26.9) | ||
Conoventricular | 101 (84.2) | 72 (77.4) | ||
Conal Septal Hypoplasia | 5 (4.2) | 4 (4.3) | ||
Malalignment | 14 (11.7) | 15 (16.1) | ||
Unspecified Type | 0 | 2 (2.2) | ||
D-Transposition of the Great Arteries | 124 (19.8) | 68 (19.6) | ||
With Ventricular Septal Defect | 61 (49.2) | 30 (44.1) | ||
Without Ventricular Septal Defect | 60 (48.4) | 33 (48.5) | ||
Unspecified if Ventricular Septal Defect Present | 3 (2.4) | 5 (7.4) | ||
Transposition of the Great Arteries - other/unknown∼ | 6 (1) | 4 (1.2) | ||
Double Outlet Right Ventricle^ | 68 (10.8) | 19 (5.5) | ||
Pulmonary Stenosis/Atresia | 28 (41.2) | 8 (42.1) | ||
Aortic Stenosis/Atresia | 9 (13.2) | 1 (5.3) | ||
Tricuspid Stenosis/Atresia | 8 (11.8) | 2 (10.5) | ||
Mitral Stenosis/Atresia | 26 (38.2) | 5 (26.3) | ||
Common Atrioventricular Valve | 6 (8.8) | 5 (26.3) | ||
Single Ventricle (Double Inlet Right or Left Ventricle) | 1 (1.5) | 1 (5.3) | ||
Isolated Aortic Arch Anomaly | 29 (4.7) | 18 (5.2) | ||
Left Aortic Arch with Aberrant Right Subclavian Artery | 1 (3.4) | 4 (22.2) | ||
Right Aortic Arch with Mirror Image Branching | 3 (10.3) | 2 (11.1) | ||
Right Aortic Arch with Aberrant Left Subclavian Artery | 9 (31.0) | 7 (38.9) | ||
Double Aortic Arch | 16 (55.2) | 5 (27.8) | ||
Truncus Arteriosus | 18 (2.9) | 16 (4.6) | ||
Type 1 | 8 (44.4) | 11 (68.8) | ||
Type 2 | 6 (33.3) | 4 (25.0) | ||
Type 3 | 1 (5.6) | 0 | ||
Type 4 | 1 (5.6) | 0 | ||
Type Unspecified | 2 (11.1) | 1 (6.3) | ||
Interrupted Aortic Arch | 12 (1.9) | 8 (2.3) | ||
Type A | 3 (25.0) | 1 (12.5) | ||
Type B | 8 (66.7) | 7 (87.5) | ||
Type Unspecified | 1 (8.3) | 0 | ||
Other # | 1 (0.1) | 2 (0.6) | ||
Total | 627 (100) | 346 (100) |
2.7% and 3.2% of the subjects were also diagnosed with heterotaxy in Cohort1 and Cohort 2, respectively.
17.5% and 14% of the subjects were also diagnosed with coarctation of the aorta in Cohort 1 and Cohort 2, respectively; and 9.2% and 6.5% had concurrent muscular VSDs in Cohort 1 and Cohort 2, respectively.
Cardiac segments SDL or unknown
Subsets are not mutually exclusive.
Single subjects with atrial septal defect and muscular VSD, muscular VSD, right ventricle aorta and pulmonary atresia.