Table 2.

Characteristics of the comparative studies included in this section

Author	Compared radiotracers	Study type (year)	Study group number	Inclusion criteria	PSA level, mean (±SD)	Time window between PET/CT scans	Detection rate
Schwenck [46]	68Ga-PSMA vs. 11C-choline	retrospective (2016)	103	BCR	2.7 (median)	24 hours	lymph nodes: 94% vs. 71% bones: 98% vs. 64% overall: 83% vs. 79%
Bluemel [44]	68Ga-PSMA vs. 18F-choline	retrospective (2016)	125	BCR	5.4 (±12.73)	51 days	18F-choline: 74.4% 68Ga-PSMA in 18F-choline(-) scans: 43.8% overall: 85.6%
Pfister [45]	68Ga-PSMA vs. 18F-choline	retrospective (2016)	66	BCR	2.7 and 2.35 (median)	n/a	per-patient analysis: PPV: 78.9% vs. 82.1% per-lesion analysis: PPV: 67.3% vs. 75.7% NPV: 88.8% vs. 96.6% ACC: 82.5% vs. 91.9%
Morigi [11]	68Ga-PSMA vs. 18F-choline	prospective (2015)	38	BCR	1.72 (±2.54)	30 days	PSA level <0.5: 50% vs. 12.5% PSA level 0.5-2.0: 71% vs. 36% PSA level >2.0: 88% vs. 63% overall: 66% vs. 32%
Afshar-Oromieh [43]	68Ga-PSMA vs. 18F-choline	retrospective (2014)	37	BCR	11.1 (±24.1)	30 days	PSA level ≤2.82: 68.8% vs. 43.5% PSA level >2.82: 100% vs. 90.5% overall: 86.5% vs. 70.3%

ACC – accuracy; BCR – biochemical recurrence; NPV – negative predictive value; PPV – positive predictive value

All PSA levels are given in ng/ml