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. Author manuscript; available in PMC: 2018 Apr 6.
Published in final edited form as: Mol Cell. 2017 Mar 16;66(1):50–62.e6. doi: 10.1016/j.molcel.2017.02.006

Figure 7. Model Illustrating the Mechanism of Action of the Fft3 Chromatin Remodeler.

Figure 7

Fft3 precludes the exchange of nucleosomes over heterochromatic as well as euchromatic loci such as highly transcribed genes and genes containing short internal repeats. Loss of Fft3 leads to unstable nucleosomes and a gradual loss of old H3K9me nucleosomes at heterochromatic regions, causing defects in the propagation of heterochromatin. At euchromatic loci, loss of Fft3 leads to an open chromatin structure and formation of R-loops and/or aberrant structures, which further destabilize nucleosomes and impede replication fork progression, causing replication defects.