Table 1.
Baseline Characteristics of Participants with Cystic Fibrosis vs Healthy Reference Subjects
| Healthy Subjects (n=28) | All CF (N = 24) | Baseline vitamin D insufficient1 (n = 12) | Baseline vitamin D sufficient (n = 12) | Vitamin D (n = 12) | Placebo (n = 12) | |
|---|---|---|---|---|---|---|
| Age (yr) | 28± 6 | 29 ± 9 | 30 ± 9 | 27 ± 9 | 25 ± 54 | 32 ± 10 |
| Male (%) | 6 (21)b | 16 (67) | 10 (83) | 6 (50) | 8 (67) | 8 (67) |
| Caucasian (%) | 18 (64.3) | 21 (88) | 9 (75) | 12 (100) | 12 (100) | 9 (75) |
| BMI (kg/m2) | 22.9 ± 0.62 | 20.3 ± 3.8 | 20.9 ± 4.5 | 19.7 ± 3.2 | 19.5 ± 3.4 | 21.1 ± 4.3 |
| F508Del homozygous (%) | ------------- | 16 (64) | 8 (67) | 8 (67) | 6 (50) | 10 (83) |
| Pancreatic insufficient (%) | ------------- | 22 (92) | 11 (92) | 11 (92) | 10 (83) | 12 (100) |
| CF-related diabetes (%) | ------------- | 13 (52) | 5 (42) | 8 (67) | 5 (42) | 8 (67) |
| FEV1(% predicted) | ------------- | 43 ± 27 | 41 ± 23 | 45 ± 31 | 47 ± 34 | 39 ± 18 |
| Spring/Summer season of blood draw (%) | 0 (0)2 | 14 (58) | 6 (43) | 8 (57) | 8 (57) | 6 (43) |
| 25(OH)D (ng/mL) | 18 ± 62 | 28 ± 13 | 18 ± 73 | 38 ± 8 | 30 ± 12 | 26 ± 14 |
| Vitamin D insufficient1 | 26 (93)2 | 12 (50) | --------- | --------- | 4 (33) | 8 (67) |
| Calcium (mg/dL) | ------------- | 8.8 (0.6) | 8.6 (0.7) | 8.9 (0.4) | 8.9 (0.4) | 8.7 (0.7) |
| Parathyroid hormone (pg/mL) | ------------- | 64.8 (56.5) | 88.0 (63.4)3 | 41.5 (38.5) | 47.9 (38.9) | 81.6 (67.4) |
1
Defined as serum 25(OH)D < 30 ng/mL.
2
Significantly different from CF subjects at P<0.01.
3
Significantly different from vitamin D sufficient group at P<0.05.
4
Significantly different from placebo group at P<0.05.