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. 2017 Apr 21;11:1283–1290. doi: 10.2147/DDDT.S133814

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© 2017 Fang et al. This work is published and licensed by Dove Medical Press Limited

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Michaelis–Menten curves of the enzymatic activity of the wild-type and 24 variants toward gefitinib O-demethylation.

Notes: Each point represents the mean ± standard deviation of three parallel experiments. The allelic variants with designated allele names have been manually arranged into six different groups: CYP2D6*1, *2, *10, *87, and *88 (A); CYP2D6*1, *94, *95, R25Q, and E215K (B); CYP2D6*1, *90, *97, V327M, and R440C (C); CYP2D6*1, *91, *93, and R497C (D); CYP2D6*1, *89, *98, V342M, and R344Q (E); CPY2D6*1, F164L, F219S, and D336N (F).

Abbreviation: CYP2D6, cytochrome P450 2D6.