Table 5. Overview of potentially novel genes identified in human steroidogenesis.
Potential function has been summarized from data in the GeneCards database, www.genecards.org
| Rank | Gene | Protein | OMIM
gene |
Potential function |
|---|---|---|---|---|
| 1 | MGARP
(OSAP) |
Mitochondria localized glutamic
acid rich protein |
- | Possible mitochondrial integrity and trafficking of
mitochondria along microtubules |
| 2 | MAP3K15
(ASK3) |
Mitogen-activated protein kinase
kinase kinase 15 |
300820 | Cell signalling of stress and apoptosis |
| 3 | HPGD | 15-hydroxyprostaglandin
dehydrogenase |
601688 | Metabolism and degradation of prostaglandins and
NAD-dependent dehydrogenation |
| 4 | C7 | Complement component 7 | 217070 | Cytolytic phase of complement activation forming
part of the membrane attack complex |
| 5 | MT2A | Metallothionein 2A | 156360 | Possible regulation of oxidative stress and binding
to metal ions |
| 6 | DLK1
(PREF1, FA1) |
Delta-like non-canonical notch
ligand 1 |
176290 | Imprinted (paternally expressed) regulator of cell
growth and differentiation |
| 7 | INHA | Inhibin alpha | 147380 | Alpha subunit of TGF-beta glycoprotein hormone
involved in regulation of hormone secretion, cell growth and apoptosis. Variants implicated in paediatric adrenal cancer. |
| 8 | FOXO4 | Forkhead box O4 | 3000033 | Transcription factor involved in oxidative stress,
growth and differentiation, and leukaemia |
| 9 | GRAMD1B | GRAM domain containing 1B | (612559) | Locus has susceptibility to chronic lymphocytic
leukaemia |
| 10 | RMDN2
(FAM82A1) |
Regulator of microtubule
dynamics 2 |
611872 | Microtubule association during cell division |
| 11 | SLC46A3 | Solute carrier family 46,
member 3 |
616764 | Membrane transport of small molecules |
| 12 | SLC16A9 | Solute carrier family 16,
member 9 |
614242 | Monocarboxylic acid transporter across plasma
membranes |
| 13 | COL15A1 | Collagen type XV, alpha-1 | 120325 | Structural component of muscle and vessels,
possible precursor of restin (antiangiogenic) |
| 14 | AVPI1 | Arginine vasopressin induced 1 | - | May be involved in MAP kinase activation and cell
cycling |
| 15 | FRRS1 | Ferric chelate reductase 1 | 611578 | Reduces ferric to ferrous iron before its transport
from the endosome to cytoplasm |
| 16 | VCAM1 | Vascular cell adhesion
molecule 1 |
192225 | Glycoprotein expressed in endothelial cells,
interacts with integrins on leukocytes to mediate adhesion and signal transduction |
| 17 | FLJ38894 | - | - |