Table 2.
Group × Timepoint Interactions Predicting Reaction Time-Blood Oxygen Level-Dependent (RT-BOLD) Relationships
| Region | x | y | z | Voxels | BA | F | ηp2 | Group Differences - Pre-stimulus | Group Differences -Peak |
|---|---|---|---|---|---|---|---|---|---|
| Right Paracentral Lobule |
2 | −36 | 59 | 64 | 5 | 2.54 | 0.06 | DMDD>ADHD=HV | HV=DMDD>ADHD |
| Left Precuneus |
−23 | −54 | 42 | 43 | 7 | 3.37 | 0.08 | DMDD=ADHD=HV | HV>DMDD=ADHD |
| Right Superior Parietal Lobule |
12 | −64 | 56 | 41 | 7 | 3.30 | 0.08 | DMDD>ADHD=HV | HV>DMDD=ADHD |
| Right Fusiform Gyrus |
51 | −40 | −11 | 27 | 37 | 2.94 | 0.07 | DMDD>ADHD=HV | HV>DMDD=ADHD |
| Right Culmen |
51 | −43 | −32 | 25 | – | 5.06 | 0.11 | DMDD>ADHD=HV | DMDD=ADHD=HV |
Note: Regions showing significant group × timepoint effects on RT-BOLD relationships (amplitude modulation) in a whole brain analysis are presented here. Coordinates (x, y, z) are presented for the peak voxel in each region as well as the number of voxels exceeding the whole brain threshold. The Brodmann area (BA) for each region is also presented. The F-statistic and partial eta squared (np2) of the group × timepoint interaction were calculated on RT-BOLD averaged across the region. All group × time interactions and main effects of time were significant (p<.007). Pair-wise group differences at the pre-stimulus timepoint (2.5 seconds before stimulus onset) and at the peak timepoint (6.25 seconds after stimulus onset) are summarized here; significant effects at p<.05 are noted in the Group Differences columns. ADHD = attention-deficit/hyperactivity disorder; DMDD = disruptive mood dysregulation disorder; HV = healthy volunteer.