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Effects of calprotectin on the cells implicated in the pathogenesis of rheumatic diseases. CLP is mainly produced by activated monocytes and granulocytes and mediates the production of pro-inflammatory cytokines and chemokines, cell activation, and apoptosis in targeted cells. CLP induces the expression of further CLP with a consequent positive autocrine and paracrine feedback loop. (A color version of this figure is available in the online journal.)
