Table 1.
Expression of molecules implicated in intestinal calcium absorption throughout development
| Duodenum |
Jejunum |
Ileum |
Cecum |
Proximal Colon |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (weeks) | <3 | 3–8 | >8 | <3 | 3–8 | >8 | <3 | 3–8 | >8 | <3 | 3–8 | >8 | <3 | 3–8 | >8 | Reference |
| Transcellular | ||||||||||||||||
| Trpv6 | Yes | Yes | Yes* | ND | ND | No | ND | ND | No | ND | ND | Yes | ND | ND | Yes | 19,22,37,55,71 |
| Cav1.3 | ND | ND | No | ND | ND | Yes | ND | ND | Yes | ND | ND | No | ND | ND | No | 29 |
| CaBP9K | Yes | Yes | Yes* | ND | Yes | No | ND | ND | No | ND | Yes | Yes | ND | ND | Yes | 19,22,33,37,55,71 |
| Pmca1 | Yes | Yes | Yes* | ND | ND | Yes | ND | ND | Yes* | ND | ND | Yes | ND | ND | Yes* | 19,22,34,35,37,55 |
| Pmca4 | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | 34 |
| Ncx1 | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | 19 |
| Paracellular | ||||||||||||||||
| Cldn2 | ND | Yes | Yes* | Yes | Yes | Yes | ND | ND | Yes* | ND | ND | Yes* | ND | ND | Yes* | 19,37,38,42 |
| Cldn12 | ND | ND | Yes* | Yes | Yes | Yes | ND | ND | Yes* | ND | ND | Yes* | ND | ND | Yes* | 19,37,38,40,42 |
| Cldn15 | ND | ND | Yes* | Yes | Yes | Yes | ND | ND | Yes* | ND | ND | Yes* | ND | ND | Yes* | 19,37,38,40,42 |
| Cldn19 | ND | ND | No | Yes | ND | No | ND | ND | No | ND | ND | No | ND | ND | No | 40 |
| Nhe3 | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | ND | ND | Yes | 19 |
Note: Ages refer to age of rodent animal models. ND, no data.
*
Expression in adult human and rodent samples.