Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 20;7(2):206–226. doi: 10.1016/j.ijpddr.2017.04.003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 16 — Schematic overview of fluoropyrimidine metabolism in T. b. brucei and Leishmania species. Red boxes and arrows represent metabolites and reactions, respectively, observed in both T. brucei and Leishmania species; Blue boxes and arrows are observed only in T. brucei and green arrows represent reactions observed only in the Leishmania species; black boxes and arrows indicate reactions that do not happen in either species. The curved blue bar schematically represents the plasma membrane of the parasites. Enzyme reactions are indicated with numbers as follows. 1, Uridine Phosphorylase and/or Thymidine Phosphorylase; 2, Uracil Phosphoribosyl transferase; 3, Nucleoside Diphosphatase; 4, Nucleoside Diphosphate Kinase; 5, Cytidine Triphosphate Synthase; 6, Ribonucleoside-diphosphate Reductase; 7, Thymidylate Kinase; 8, Thymidine Kinase; 9, UTP:N-acetyl-a-D-glucosamine-1-phosphate Uridylyltransferase; 10, UDP-Glucose Pyrophosphorylase; 11, UDP-Glucose Epimerase; 12, Phosphatidate Cytidylyltransferase; 13, Ethanolamine-phosphate Cytidylyltransferase; 14, Choline-phosphate Cytidylyltransferase; 15, RNA Polymerase.