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. 2017 Apr 27;12(4):e0176412. doi: 10.1371/journal.pone.0176412

Fig 1. Myocardial perfusion increased after injection of 4 million cell/Kg.

Fig 1

MBF was calculated by RTMPE. The highest dose of pASC increased myocardial blood flow (MBF) on both, remote and border areas of MI. A) MBF before and after cell injection for both non-infarcted (left chart) and infarcted (right chart) segments for each animal of the 4 experimental groups. B) MBF averaged value for each experimental group, normalized by the respective MBF averaged value before cell injection (difference are significant between 4 million cell/Kg injection animals before and after cell transplantation, *** p<0.0005 and ** p<0.005 to non-infarcted and infarcted segments respectively, Two-way ANOVA with Bonferroni post-test). C) ΔMBF from remote and border areas (ΔMBF = (MBF after cell injection)–(MBF before cell injection)), (differences are significant between 4 million cell/Kg injection and placebo groups in the infarcted segment, * p<0.05, One-way ANOVA with Bonferroni post-test). D) MBF ratio was calculated by averaged value for each experimental group, normalized by MBF average value of the placebo group (differences are significant between 4 million cell/Kg injection and placebo group (for each are separately), * p<0.05 for both remote and border area, One-way ANOVA with Bonferroni post-test). E) LVEF assessed by echocardiography and calculated from linear measurements before (30 days after MI induction) and 30 days after cells injections for each experimental group. F) ΔLVEF from percentage of LVEF after and before treatments (ΔLVEF = (LVEF after cell injection)–(LVEF before cell injection)). All data are means ± SEM.