Table 1.
Patients characteristics
| Characteristics | All | Responder | Non-responder | p-value | |
|---|---|---|---|---|---|
| N | 40 | 14 | 26 | ||
| Median age | (range) | 62 (41–86) | 69 (47–83) | 63 (41–86) | 0.387 |
| WBC count (x109/l) | Median (range) | 8.7 (1.1–89) | 10.5 (2.3–35.3) | 8.7 (1.1–89) | 0.379 |
| Hemoglobin (g/l) | Median (range) | 9.8 (7.8–17.3) | 9.6 (7.8–17.3) | 10.2 (8.4–15.4) | 0.327 |
| Platelet count (x109/l) | Median (range) | 237 (8–1183) | 217 (68–1183) | 242 (8–1005) | 0.590 |
| Peripheral blood blasts (%) | Median (range) | 0 (0–17) | 0 (0–2) | 1 (0–17) | 0.003 |
| Bone marrow blasts (%) | Median (range) | 2 (0–14) | 1 (0–4) | 2 (0–14) | 0.715 |
| Spleen size BCM (cm) | Median (range) | 10 (0–25) | 11 (0–22) | 5 (0–25) | 0.836 |
| Previously treated | 30 (75%) | 10 (71%) | 20 (77%) | 0.178 | |
| No. of prior therapies | Median(range) | 1 (1–4) | 1 (1–3) | 1 (1–4) | 0.324 |
| JAK2V671F mutation | 20 (50%) | 9 (64%) | 11 (42%) | 0.320 | |
| Karyotype | Diploid | 24 (60%) | 7 (50%) | 17 (65%) | 0.198 |
| Abnormal | 16 (40%) | 7 (50%) | 9 (35%) |
Abbreviations: WBC, white blood cell; BCM, below costal margin