Table 4.
Associations of top single nucleotide polymorphisms with mineral metabolism measurements
| SNP and Nearest Gene | PTH, pg/ml | FGF23, pg/ml | 24,25D, ng/ml | 25D, ng/ml | Serum Calcium, mg/dl | Serum Phosphorus, mg/dl | Urine Calcium-to-Creatinine Ratio, mg/mg | Urinary FePO4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean (SD) | N | Mean (SD) | N | Mean(SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | |
| rs6127099 | ||||||||||||||||
| CYP24A1 | ||||||||||||||||
| AA | 5164 | 38.88 (10.5) | 5164 | 44.17 (11.3) | 1244 | 4.54 (2.7) | 5164 | 27.93 (6.7) | 6638 | 9.44 (0.24) | 6638 | 3.57 (0.3) | 1244 | 0.102 (0.07) | 1244 | 12.71 (5.7) |
| AT | 3906 | 41.76 (11.1) | 3906 | 42.24 (12.9) | 1009 | 4.51 (2.7) | 3906 | 27.17 (6.6) | 5041 | 9.44 (0.24) | 5041 | 3.57(0.3) | 1009 | 0.102 (0.07) | 1009 | 12.62 (5.3) |
| TT | 703 | 44.08 (11.8) | 703 | 40.83 (10.2) | 202 | 4.69 (2.8) | 703 | 27.16 (6.1) | 907 | 9.45 (0.26) | 907 | 3.55 (0.3) | 202 | 0.090 (0.06) | 202 | 11.78 (5.3) |
| P-for-trenda | <0.001 | <0.001 | 0.46 | 0.004 | 0.33 | 0.02 | 0.03 | 0.03 | ||||||||
| rs4074995 | ||||||||||||||||
| RGS14 | ||||||||||||||||
| AA | 830 | 37.22 (9.19) | 830 | 40.79 (9.97) | 202 | 4.66 (2.8) | 830 | 28.02 (6.6) | 1053 | 9.45 (0.25) | 1053 | 3.52 (0.3) | 202 | 0.105 (0.07) | 202 | 12.44 (5.0) |
| GA | 4173 | 40.08 (11.1) | 4173 | 42.78 (12.3) | 968 | 4.49 (2.6) | 4173 | 27.59 (6.6) | 5416 | 9.44 (0.24) | 5416 | 3.56 (0.3) | 968 | 0.101 (0.07) | 968 | 12.70 (5.4) |
| GG | 5587 | 41.23 (11.1) | 5587 | 43.69 (11.7) | 1285 | 4.55 (2.7) | 5587 | 27.44 (6.6) | 7109 | 9.44 (0.24) | 7109 | 3.58 (0.3) | 1285 | 0.101 (0.07) | 1285 | 12.54 (5.7) |
| P-for-trend | <0.001 | <0.001 | 0.59 | 0.02 | <0.001 | <0.001 | 0.46 | 0.81 | ||||||||
| rs219779 | ||||||||||||||||
| CLDN14 | ||||||||||||||||
| AA | 645 | 39.12 (11.2) | 645 | 44.46 (12.4) | 168 | 4.53 (2.5) | 645 | 27.63 (6.5) | 828 | 9.45 (0.23) | 828 | 3.58 (0.3) | 168 | 0.087 (0.06) | 168 | 12.09 (5.2) |
| AG | 3823 | 39.91 (10.6) | 3823 | 42.98 (11.7) | 907 | 4.55 (2.7) | 3823 | 27.41 (6.6) | 4858 | 9.44 (0.24) | 4858 | 3.57 (0.3) | 907 | 0.104 (0.07) | 907 | 12.56 (5.3) |
| GG | 5878 | 40.89 (11.0) | 5878 | 43.03 (12.1) | 1380 | 4.53 (2.7) | 5878 | 27.62 (6.6) | 7647 | 9.45 (0.24) | 7647 | 3.57 (0.3) | 1380 | 0.101 (0.07) | 1380 | 12.68 (5.7) |
| P-for-trend | 0.001 | 0.004 | 1.00 | 0.99 | 0.65 | 0.39 | 0.02 | 0.19 | ||||||||
| rs4443100 | ||||||||||||||||
| RTDR1 | ||||||||||||||||
| CC | 4898 | 39.90 (10.7) | 4898 | 43.60 (13.1) | 1188 | 4.48 (2.6) | 4898 | 27.56 (6.5) | 6246 | 9.46 (0.24) | 6246 | 3.57 (0.3) | 1188 | 0.099 (0.07) | 1188 | 12.62 (5.4) |
| CG | 4406 | 40.86 (11.2) | 4406 | 42.73 (11.2) | 1014 | 4.61 (2.7) | 4406 | 27.73 (6.7) | 5680 | 9.42 (0.25) | 5680 | 3.57 (0.3) | 1014 | 0.102 (0.07) | 1014 | 12.52 (5.8) |
| GG | 994 | 41.74 (11.3) | 994 | 42.64 (10.1) | 253 | 4.52 (2.8) | 994 | 26.87 (6.5) | 1340 | 9.43 (0.23) | 1340 | 3.58 (0.3) | 253 | 0.107 (0.07) | 253 | 12.80 (5.1) |
| P-for-trend | <0.001 | 0.02 | 0.83 | 0.003 | 0.001 | 0.20 | 0.11 | 0.64 | ||||||||
| rs73186030 | ||||||||||||||||
| CASR | ||||||||||||||||
| CC | 7817 | 40.00 (10.9) | 7817 | 43.05 (12.3) | 1746 | 4.54 (2.7) | 7817 | 27.61 (6.7) | 9916 | 9.41 (0.24) | 9916 | 3.59 (0.3) | 1746 | 0.101 (0.07) | 1746 | 12.45 (5.6) |
| CT | 2456 | 41.76 (11.3) | 2456 | 43.32 (11.4) | 636 | 4.52 (2.5) | 2456 | 27.37 (6.5) | 3264 | 9.51 (0.24) | 3264 | 3.53 (0.3) | 636 | 0.102 (0.07) | 636 | 12.94 (5.5) |
| TT | 212 | 42.15 (10.4) | 212 | 42.98 (9.68) | 73 | 4.60 (2.6) | 212 | 27.17 (5.5) | 283 | 9.55 (0.21) | 283 | 3.53 (0.3) | 73 | 0.103 (0.07) | 73 | 13.03 (4.8) |
| P-for-trend | 0.01 | 0.94 | 0.85 | 0.35 | <0.001 | 0.001 | 0.81 | 0.38 | ||||||||
24,25D, 24,25-dihydroxyvitamin D; 25D, 25-hydroxyvitamin D; FePO4, Fractional excretion of phosphorus.
a
P-for-trend obtained from Wald test of linear regression coefficient for number of copies of the minor allele.