Table 5.
Analysis of gene-gene interaction: ORs for iMN according to SNP rs4664308 (PLA2R1) and HLA-DRB1*1501/DRB1*0301 combinations
| SNP rs4664308 (PLA2R1) | HLA-DRB1*1501 | HLA-DRB1*0301 | ||
|---|---|---|---|---|
| (−) | (+) | (−) | (+) | |
| GG (low risk) | ||||
| No. of patients/controls | 2/30 | 2/10 | 3/37 | 1/3 |
| OR (95% CI) | 1 | — | 1 | — |
| P value | Reference | 0.30 | Reference | 0.33 |
| GA (moderate risk) | ||||
| No. of patients/controls | 21/133 | 14/38 | 23/153 | 12/18 |
| OR (95% CI) | — | 5.53 (1.17 to 26.22) | — | 8.22 (2.06 to 32.84) |
| P value | 0.38 | 0.02 | 0.43 | 0.002 |
| AA (high risk) | ||||
| No. of patients/controls | 51/137 | 108/50 | 125/173 | 34/14 |
| OR (95% CI) | 5.58 (1.79 to 24.21) | 32.40 (7.45 to 140.94) | 8.91 (2.69 to 29.55) | 29.95 (7.91 to 113.37) |
| P value | 0.01 | <0.001 | <0.001 | <0.001 |
95% CI, 95% confidence interval; —, P>0.05.