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. 2016 Dec 8;28(5):1507–1520. doi: 10.1681/ASN.2016020169

Figure 2.

Figure 2.

The bicarbonate transporter NBCn1 shows a compensatory increase in Ae1+/R607H and Ae1R607H/R607H mice. (A) Protein abundance of pH relevant transporters NBC1, NHE3, NBCn1, and AE2 in protein lysates from whole kidney tissue under baseline conditions. Ae1+/+ (n=5), Ae1+/R607H (n=5), and Ae1R607H/R607H (n=4). (B) Quantification of NBC1, NHE3, NBCn1, and AE2 protein abundance. The abundance of NBCn1 is strongly increased in Ae1+/R607H and Ae1R607H/R607H mice. Data are presented as mean±SEM. ***P<0.001; ****P<0.0001 (one-way ANOVA). (C–E) Fluorescence intensity for NBCn1 is increased in the TAL of knockin mice. Ae1 (green), NBCn1 (red). Scale bar: 30 µm.