Table 2.

Multivariate regression analysis investigating the effect of various parameters on baseline fasted Uosm

Variable	Coefficient (Anti-Log)	SEM	P Value
Age, yr	0.999	1.002	0.62
Sex	1.131	1.034	0.003
Race (white versus nonwhite)	1.068	1.034	0.048
Hypertension	0.901	1.048	0.03
Log of baseline TKV, ml	0.746	1.073	<0.001
Baseline eGFR (CKD-EPI), ml/min per 1.73 m2	1.004	1.001	<0.001
Albumin/creatinine ratio, mg/mmol	0.999	1.001	0.13

Fasted Uosm is expressed in (log Uosm). Baseline eGFR, TKV, hypertension status, race, and sex significantly affect baseline Uosm. For continuous variables, such as baseline eGFR, when other factors are held constant, the baseline Uosm increases 1.004 times for every 1 ml/min per 1.73 m² increase in baseline eGFR. For baseline TKV, for a multiplier change, the baseline Uosm will be changed by times the 0.746 power of the multiplier. For example, if the multiplier is equal to 2 (doubling of TKV), the baseline Uosm will be changed to the original Uosm times 2^0.746. For binary variables, such as race or hypertension status, when other factors are held constant, a white subject has a baseline Uosm 1.068 times a nonwhite subject; a subject with hypertension has a baseline Uosm 0.901 times a nonhypertension subject; and a male subject has a baseline Uosm 1.131 times a female subject. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; ACR, albumin-to-creatinine ratio