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. 2016 Nov 28;28(5):1399–1407. doi: 10.1681/ASN.2016080913

Figure 2.

Figure 2.

Proximal tubulopathy is observed in cDKO mice. (A) Immunoblots of urine retinol binding protein, vitamin D binding protein, and albumin normalized to urine creatinine concentration. (B and C) Quantification of immunoblots in A standardized to urine from cDKO at 1 month. *P<0.05 (n=3). (D and E) Quantification of (D) urine phosphate and (E) calcium normalized to urine creatinine at 0, 1, 2, 3, and 4 months after doxycycline induction (black triangle, control; blue circle, Ocrl KO; and red square, cDKO mice). *P<0.05 (n=5). (F) Quantification of urine albumin normalized to urine creatinine at 3 months after doxycycline induction. *P<0.05 (n=5). (G) Blood bicarbonate (HCO3−) concentration and (H) blood pH at 0, 2, and 4 months after doxycycline induction (black triangle, control; blue circle, Ocrl KO; and red square, cDKO mice). *P<0.05 (n=5).