Figure 1.
High salt–induced production of NO is impaired in the Dahl/Rapp SS rat. Infusion of NG-monomethyl-l-arginine (L-NMMA) was used to determine the component of mean arterial pressure (MAP) that was dependent on NO production in young animals. Increased dietary salt intake increased the BP responses to L-NMMA in Dahl/Rapp SR and Sprague–Dawley rats but not in Dahl/Rapp SS rats. In these experiments, rats were fed for 2 weeks a diet that contained 0.3% NaCl, 8.0% NaCl, or 8.0% NaCl with either d-arginine as a control, because it cannot be used to produce NO, or l-arginine in the drinking water. SD, Sprague–Dawley. Modified from ref. 1, with permission.