Table 3. Association of HOMA-IR index with hot flash status and adipocyte-derived hormones.
| Variable | HOMA-IR index | |||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | |
| Hot flashes | ||||
| None | ||||
| Mild to moderate | 10.83(-8.58,34.36) | 3.79 (-13.27,24.2) | 0.85 (-15.35,20.15) | 1.15 (-15.12,20.55) |
| Severe | 58.03(31.00,90.64)c | 29.13 (6.99,55.85)b | 18.22 (-2.32,43.09) | 19.09 (-1.82,44.45) |
| Leptin | 3.3 (1.85,4.77)c | 3.07 (1.66,4.5)c | 3.06 (1.65,4.49)c | |
| Adiponectin-1 | 21.86 (7.45,38.2)b | 22 (7.58,38.36)b | ||
| Resistin | 0.23 (-0.72,1.19) | |||
Data are expressed as the percentage difference (95% CI). HOMA-IR index was log-transformed.
Regression coefficients were back-transformed using the formula (100*(exp(β)-1)) to calculate the percentage difference and the 95% CI in HOMA-IR index for hot-flash group relative to non-hot flash group.
Model 1: univariate linear regression model for HOMA-IR index; Model 2: adjusted for hot flash status, follicle stimulating hormone, body mass index, age, and menopause duration, and Leptin; Model 3: adjusted for Model 2 plus adiponectin-1; Model 4: adjusted for Model 3 plus resistin.
Adiponectin-1, the inverse of adiponectin level
b P < .01
c P < .001.