Table 2. Linear regression analysis.
| Univariate analysis | Multivariate analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | CC | p-values | n | Sex | S-P | cFGF23 | U-Ca/U-crea | CEI | U-P/U-crea | PEI | U-AG | Multiple |
| S-Ca | 0.12 | 0.4 | 60 | <0.0001 | 1.0 | 0.6 | 0.0001 | 0.0009 | 0.03 | 0.02 | 0.5 | 0.3 |
| S-P | 0.39 | 0.004 | 55 | 0.006 | 0.004 | 0.009 | 0.1 | 0.1 | 0.01 | 0.1 | 0.01 | 1.0 |
| S-BUN | 0.07 | 0.6 | 59 | 0.3 | 0.03 | 0.7 | 0.1 | 0.1 | 0.68 | 0.2 | 0.2 | 1.0 |
| PTH | 0.05 | 0.7 | 48 | 0.0003 | 0.3 | 0.3 | 0.03 | 0.1 | 1.0 | 0.8 | 0.4 | 0.4 |
| cFGF23 | 0.36 | 0.01 | 49 | 0.01 | 0.004 | 0.01 | 0.009 | 0.003 | 0.03 | 0.03 | 0.2 | 0.2 |
| 1,25-D | -0.01 | 1.0 | 46 | 0.7 | 0.9 | 0.7 | 0.7 | 0.8 | 0.5 | 0.5 | 0.2 | 0.7 |
| U-Ca/U-crea | 0.49 | <0.0001 | 59 | <0.0001 | 0.004 | 0.001 | <0.0001 | 0.009 | 0.0008 | 0.002 | 0.002 | 0.8 |
| CEI | 0.39 | 0.003 | 57 | 0.0002 | 0.03 | 0.01 | 0.4 | 0.002 | 0.01 | 0.03 | 0.008 | 0.4 |
| U-P/U-crea | -0.27 | 0.04 | 59 | 0.04 | 0.04 | 0.1 | 0.4 | 0.23 | 0.04 | 0.81 | 0.6 | 0.4 |
| PEI | -0.37 | 0.008 | 53 | 0.01 | 0.2 | 0.003 | 0.1 | 0.08 | 0.2 | 0.008 | 0.3 | 0.4 |
| U-P*U-Ca/U-crea | 0.23 | 0.09 | 57 | 0.2 | 0.7 | 0.2 | 0.1 | 0.7 | 0.02 | 0.09 | 0.01 | 0.02 |
| U-Citrate/U-crea | 0.15 | 0.4 | 32 | 0.4 | 0.5 | 0.5 | 0.2 | 0.2 | 0.3 | 0.3 | 0.94 | 0.6 |
| U-oxalate/U-crea | 0.20 | 0.3 | 33 | 0.4 | 0.34 | 0.6 | 0.2 | 0.07 | 0.09 | 0.1 | 0.3 | 0.1 |
| U-AG | -0.42 | 0.01 | 35 | 0.02 | 0.008 | 0.1 | 0.06 | 0.04 | 0.03 | 0.008 | 0.01 | 0.001 |
Following univariate linear regression analysis of all experimental Npt2a-/- mice analysis of covariance (multivariate analysis) was used to control for influence of gender, variables separately as indicated in the column header or to control for multiple variables (S-P, cFGF23, U-Ca/U-crea, CEI, U-P/U-crea, PEI, U-AG). The number of animals included for each diet is shown in S1 Table.