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. 2017 Apr 27;12(4):e0176386. doi: 10.1371/journal.pone.0176386

Fig 1.

Fig 1

A: Pedigrees of congenital glaucoma families included in this study. CYP1B1 genotypes are indicated below the symbols. Arrows show probands. Blue symbols indicate glaucoma phenotypes. Carriers are denoted by black dots in symbols; +: wild-type allele. Genealogy PCG 49 has previously been reported [6, 24] B: Location in the polypeptide chain of the CYP1B1 mutations identified in the probands. Alpha-helix regions are indicated in green and indicated with capital letters (A’-K). βS: beta-sheet regions (blue box). The numbers above the scheme correspond to amino acid positions.