Table 2. Enriched pathways based on the islet proteomics data set from a single donor.

Name	Total Entities	Expanded # of Entities	Overlap	Percent Overlap	p-value
Insulin Action	50	912	242	26	5.00E-47
EphrinR -> actin signaling	15	216	49	22	9.49E-18
Mitochondrial Protein Transport	25	111	45	40	1.82E-16
Actin Cytoskeleton Assembly	31	55	28	50	1.19E-13
B Cell Activation	62	847	159	18	6.74E-13
Tight Junction Assembly (Occludin)	38	294	69	23	9.14E-11
Ubiquitin-dependent Protein Degradation	15	125	38	30	1.26E-09
rRNA Transcription and Processing	35	292	58	19	1.96E-06
Notch Pathway	40	1487	214	14	4.38E-06
Adipocytokine Signaling	52	792	122	15	5.05E-05
Presentation of Endogenous Peptide Antigen	16	69	19	27	9.30E-05
Cell Cycle Regulation	135	2179	275	12	0.00346734
SomatostatinR -> ATF1/TP53 signaling	8	26	6	23	0.00731706
VasopressinR2 -> STAT signaling	7	7	3	42	0.00946125
FSHR -> CREB/ELK-SRF/GATA4 signaling	29	88	12	13	0.0159035
IGF1R -> STAT signaling	9	9	3	33	0.0204864
InsulinR -> STAT signaling	9	9	3	33	0.0204864
GlucagonR -> CREB/ELK-SRF/SP1 signaling	20	42	7	16	0.0233242
FSHR -> FOXO1A signaling	9	54	8	14	0.0302631

Enriched pathways identified using all proteins detected (n = 1429) in one of the donors. Proteins were uploaded into Pathway Studio and pathways with a p-value of less than 0.05 identified. “Total” refers to the total number of nodes in the pathway, some of which may be complex/container entities e.g. containing numerous proteins that are all of one functional class; “Expanded # of” refers to the total number of child concepts contained within the complex entities; “Overlap” refers to the number of proteins detected in the experimental dataset which overlap with the child concepts; “Percent” refers to the percentage of complex/container entities in which at least one experimental protein was detected.