Fig 7. Microarray heat-map analysis of MCF-7 breast cancer cells treated with tomato fruit extracts originated from control and transgenic tomato lines.

The analysis shows the genes that demonstrate changes in expression after treatment with total metabolite extract from transgenic lines (L6 and L7) and control line (WT) compared to non-treated cells (NC). The MCF-7 cells were incubated with the tomato fruits extracts (1μg/ml) for 24 hrs, after which the cells were harvested and the total RNA was extracted. The genes with significant change in expression were selected after statistical analysis using ANOVA statistical test using a p-value <0.001 and Tukey post-hoc test. Only the genes with identified functions are displayed. The range of fold change of identified genes is from -0.5 to 0.5.