Table 2. Summary of the coefficients used for IV ratio analyses.
| IV | Risk Score with the Intermediate Trait | Risk score with the Outcome | IV Ratio | |
|---|---|---|---|---|
| Coefficient (95% CI) | Coefficient (95% CI) | Coefficient (95% CI) | P value | |
| wGRSBMI | 0.022 (0.019–0.026) | -0.006 (-0.009–-0.002) | -0.25 (-0.42–-0.09) | 0.003 |
| uwGRSBMI | 0.020 (0.016–0.023) | -0.006 (-0.009–-0.002) | -0.29 (-0.48–-0.10) | 0.003 |
| wGRST | -0.281 (-0.320–-0.242) | -0.020 (-0.060–0.020) | 0.07 (-0.56–0.70) | 0.214 |
| uwGRST | -0.191 (-0.220–-0.162) | -0.004 (-0.034–0.025) | 0.02 (-0.13–0.18) | 0.777 |
IV ratio was calculated as the ratio between the genetic risk score's association with the outcome and intermediate trait (n = 7446).
Coefficients for intermediate trait and outcome are given as SD per unit in genetic risk score.
wGRSBMI = Weighted genetic risk score on BMI.
uwGRSBMI = Un-weighted genetic risk score on BMI
wGRST = Weighted genetic risk score on serum testosterone.
uwGRSTT = Un-weighted genetic risk score on serum testosterone.
IV ratio is expressed in SD testosterone per SD ln-transformed BMI for wGRSBMI and uwGRSBMI, while it is expressed in SD ln-transformed BMI per SD testosterone for wGRST and uwGRST.