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. 2017 Apr 27;12(4):e0176358. doi: 10.1371/journal.pone.0176358

Table 1. Autoantibodies tested in the present study, associated clinical syndromes and frequent symptoms (adapted from Wandinger et al 2011).

Autoantibody Clinical syndrome Frequent symptoms
Anti-glutamate receptor (type NMDA) Anti-glutamate receptor (type NMDA) encephalitis Psychosis, memory-/language impairment, seizures, impaired consciousness, dyskinesia, movement disorders, dysautonomia, hypoventilation
Anti-glutamate receptor (type AMPA) Limbic encephalitis, atypical psychosis Memory deficits, confusion, disorientation, seizures, agitation, aggressive behaviour
Anti-GABAB receptor Limbic encephalitis Seizures, confusion, memory deficits, behavioural disorders, paranoia, hallucinations
Anti-LGI1 Limbic encephalitis Epilectic seizures, memory deficits, confusion, dis- orientation, hyponatriaemia, myoclonus, dysautonomia
Anti-CASPR2 Neuromyotonia, Morvan‘s syndrome, Limbic encephalitis Peripheral neuronal hyperexcitability, muscle spasms/ fasciculations/myokymia, seizures, memory deficits, confusion, disorientation, neuropathic pains, sleeping disorders, dysautonomia, weight loss
Anti-DPPX Autoimmune encephalitis Anxiety, forgetfulness, confusion, hallucinations, muscle spasms, tremor and pleocytosis (in CSF)

Abbreviations: NMDA: N-methyl-D-aspartate, AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, GABA: γ-amino butyric acid, LGI1: leucine-rich glioma-inactivated protein 1, CASPR2: contactin-associated protein 2, DPPX: dipeptidyl aminopeptidase-like protein 6