Table 1. Autoantibodies tested in the present study, associated clinical syndromes and frequent symptoms (adapted from Wandinger et al 2011).
Autoantibody | Clinical syndrome | Frequent symptoms |
---|---|---|
Anti-glutamate receptor (type NMDA) | Anti-glutamate receptor (type NMDA) encephalitis | Psychosis, memory-/language impairment, seizures, impaired consciousness, dyskinesia, movement disorders, dysautonomia, hypoventilation |
Anti-glutamate receptor (type AMPA) | Limbic encephalitis, atypical psychosis | Memory deficits, confusion, disorientation, seizures, agitation, aggressive behaviour |
Anti-GABAB receptor | Limbic encephalitis | Seizures, confusion, memory deficits, behavioural disorders, paranoia, hallucinations |
Anti-LGI1 | Limbic encephalitis | Epilectic seizures, memory deficits, confusion, dis- orientation, hyponatriaemia, myoclonus, dysautonomia |
Anti-CASPR2 | Neuromyotonia, Morvan‘s syndrome, Limbic encephalitis | Peripheral neuronal hyperexcitability, muscle spasms/ fasciculations/myokymia, seizures, memory deficits, confusion, disorientation, neuropathic pains, sleeping disorders, dysautonomia, weight loss |
Anti-DPPX | Autoimmune encephalitis | Anxiety, forgetfulness, confusion, hallucinations, muscle spasms, tremor and pleocytosis (in CSF) |
Abbreviations: NMDA: N-methyl-D-aspartate, AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, GABA: γ-amino butyric acid, LGI1: leucine-rich glioma-inactivated protein 1, CASPR2: contactin-associated protein 2, DPPX: dipeptidyl aminopeptidase-like protein 6