Table 1.

Summary of the main cellular responses observed in experiments of combined environmental stimulation. Cellular responses were included in the corresponding stimulation condition if the measured parameter was significantly different from the parameter at reference condition PX(5% O₂)/0% strain (single arrow ↑) and if more than two-fold significant difference was observed compared to PX(5% O₂)/0% strain condition (double arrow ↑↑). Different background cell color are added as a function of the number of significant cellular responses observed (yellow: 2 or less changes; orange: up to 5 changes; red: more than 5 changes).

DOI: http://dx.doi.org/10.7554/eLife.22847.012

	0% Strain	2% Strain	8% Strain
HX (1% O2)	↑↑ Mitosis ↑↑ Nuclear YAP ↑↑ PDGF ↑ Collagen ↓ MMP-3	↑ Mitosis ↑ Nuclear YAP ↑↑ PDGF ↑ Collagen ↑↑ MMP-2–3 ↑↑TGF-β ↑ IL-1β	↑ Collagen ↑ MMP-2
PX (5% O2)	Reference condition	↑ Mitosis ↑↑ Nuclear YAP ↓ MMP-3	↑ Collagen ↓ MMP-3