TABLE II.
Univariate analysis of the effect of pre-transplantation variables on overall survival
| Variable | HR | 95% CI | p Value |
|---|---|---|---|
| Sex | |||
| Men | 1 | ||
| Women | 0.6 | 0.3 to 1.19 | 0.14 |
| Duration of first remission | |||
| <6 Months | 1 | ||
| ≥6 Months | 0.88 | 0.38 to 2.04 | 0.77 |
| Patient age group | |||
| ≤55 Years | 1 | ||
| >55 Years | 0.71 | 0.32 to 1.55 | 0.39 |
| Cytogenetic risk category | |||
| Favourable | 1.05 | 0.48 to 2.29 | 0.91 |
| Intermediate or poor | 1 | ||
| Post myelodysplastic syndrome | |||
| No | 1 | ||
| Yes | 0.67 | 0.2 to 2.24 | 0.52 |
| Primary induction failure | |||
| No | 1 | ||
| Yes | 0.45 | 0.1 to 1.92 | 0.28 |
| Regimen | |||
| Myeloablative conditioning and total body irradiation | 1.1 | 0.47 to 2.58 | 0.83 |
| Myeloablative conditioning | 0.91 | 0.4 to 2.06 | 0.83 |
| Reduced-intensity conditioning | 1 | ||
| Donor type | |||
| Matched unrelated donor | 1 | ||
| Related (sibling or non-sibling) | 0.84 | 0.43 to 1.65 | 0.61 |
| Human leukocyte antigen | |||
| Match | 1.31 | 0.46 to 3.77 | 0.62 |
| Mismatch | 1 | ||
| Blood type match | |||
| Match | 1 | ||
| Minor mismatch | 1 | 0.46 to 2.2 | 1 |
| Major mismatch | 0.8 | 0.3 to 2.12 | 0.65 |
| Cytomegalovirus risk | |||
| No | 1 | ||
| Yes | 0.57 | 0.29 to 1.14 | 0.11 |
| HCT-CI score | |||
| ≤3 | 1 | ||
| >3 | 1.4 | 0.73 to 2.7 | 0.31 |
| Female donor, male recipient | |||
| No | 1 | ||
| Yes | 1.36 | 0.63 to 2.92 | 0.43 |
| Age of donor | |||
| ≤40 Years | 1 | ||
| >40 Years | 0.6 | 0.29 to 1.21 | 0.15 |
| mEBMT score | |||
| ≤3 | 1 | ||
| >3 | 1.74 | 0.89 to 3.4 | 0.11 |
HR = hazard ratio; CI = confidence interval; HCT-CI = hematopoietic cell transplantation–specific comorbidity index; mEBMT = modified European Society for Blood and Marrow Transplantation.