TABLE III.
Univariate analysis of the effect of pre-transplantation variables on relapse rate
| Variable | HR | 95% CI | p Value |
|---|---|---|---|
| Sex | |||
| Men | 1 | ||
| Women | 0.34 | 0.12 to 0.93 | 0.04 |
| Duration of first remission | |||
| <6 Months | 1 | ||
| ≥6 Months | 0.74 | 0.25 to 2.22 | 0.59 |
| Patient age group | |||
| ≤55 Years | 1 | ||
| >55 Years | 1.13 | 0.43 to 2.94 | 0.81 |
| Cytogenetic risk category | |||
| Favourable | 0.98 | 0.35 to 2.71 | 0.96 |
| Intermediate or poor | 1 | ||
| Post myelodysplastic syndrome | |||
| No | 1 | ||
| Yes | 1.2 | 0.28 to 5.19 | 0.81 |
| Primary induction failure | |||
| No | 1 | ||
| Yes | 1.71 | 0.5 to 5.83 | 0.39 |
| Regimen | |||
| Myeloablative conditioning and total body irradiation | 0.4 | 0.12 to 1.34 | 0.14 |
| Myeloablative conditioning | 0.65 | 0.24 to 1.74 | 0.39 |
| Reduced-intensity conditioning | 1 | ||
| Donor type | |||
| Matched unrelated donor | 1 | ||
| Related (sibling or non-sibling) | 1.57 | 0.62 to 3.93 | 0.34 |
| Human leukocyte antigen | |||
| Match | 2.99 | 0.4 to 22.32 | 0.29 |
| Mismatch | 1 | ||
| Blood type match | |||
| Match | 1 | ||
| Minor mismatch | 0.8 | 0.26 to 2.42 | 0.69 |
| Major mismatch | 0.5 | 0.11 to 2.18 | 0.35 |
| Cytomegalovirus risk | |||
| No | 1 | ||
| Yes | 0.77 | 0.32 to 1.87 | 0.56 |
| HCT-CI score | |||
| ≤3 | 1 | ||
| >3 | 0.98 | 0.4 to 2.4 | 0.97 |
| Female donor, male recipient | |||
| No | 1 | ||
| Yes | 1.89 | 0.72 to 4.97 | 0.2 |
| Age of donor | |||
| ≤40 Years | 1 | ||
| >40 Years | 0.67 | 0.27 to 1.68 | 0.39 |
| mEBMT score | |||
| ≤3 | 1 | ||
| >3 | 0.99 | 0.37 to 2.61 | 0.98 |
HR = hazard ratio; CI = confidence interval; HCT-CI = hematopoietic cell transplantation–specific comorbidity index; mEBMT = modified European Society for Blood and Marrow Transplantation.