TABLE IV.
Univariate analysis of the effect of pre-transplantation variables on non-relapse mortality
| Variable | HR | 95% CI | p Value |
|---|---|---|---|
| Sex | |||
| Male | 1 | ||
| Female | 0.96 | 0.37 to 2.51 | 0.94 |
| Duration of first remission | |||
| <6 Months | 1 | ||
| ≥6 Months | 0.73 | 0.23 to 2.3 | 0.59 |
| Patient age | |||
| ≤55 Years | 1 | ||
| >55 Years | 0.5 | 0.14 to 1.77 | 0.29 |
| Cytogenetic risk category | |||
| Favourable | 1.03 | 0.31 to 3.39 | 0.97 |
| Intermediate or poor | 1 | ||
| Post myelodysplastic syndrome | |||
| No | 1 | ||
| Yes | 0.89 | 0.19 to 4.13 | 0.88 |
| Primary induction failure | |||
| No | 1 | ||
| Yes | NA | NA | 0.99 |
| Regimen | |||
| Myeloablative conditioning and total body irradiation | 2.78 | 0.71 to 10.93 | 0.14 |
| Myeloablative conditioning | 1.4 | 0.35 to 5.64 | 0.63 |
| Reduced-intensity conditioning | 1 | ||
| Donor type | |||
| Matched unrelated donor | 1 | ||
| Related (sibling or non-sibling) | 0.53 | 0.19 to 1.45 | 0.21 |
| Human leukocyte antigen | |||
| Match | 0.86 | 0.24 to 3.1 | 0.81 |
| Mismatch | 1 | ||
| Blood type match | |||
| Match | 1 | ||
| Minor mismatch | 1.33 | 0.44 to 4.08 | 0.62 |
| Major mismatch | 1.05 | 0.28 to 3.99 | 0.94 |
| Cytomegalovirus risk | |||
| No | 1 | ||
| Yes | 0.44 | 0.15 to 1.26 | 0.13 |
| HCT-CI score | |||
| ≤3 | 1 | ||
| >3 | 1.93 | 0.73 to 5.08 | 0.18 |
| Female donor, male recipient | |||
| No | 1 | ||
| Yes | 0.81 | 0.23 to 2.9 | 0.75 |
| Age of donor | |||
| ≤40 Years | 1 | ||
| >40 Years | 0.53 | 0.18 to 1.59 | 0.26 |
| mEBMT score | |||
| ≤3 | 1 | ||
| >3 | 2.68 | 1.01 to 7.16 | 0.049 |
HR = hazard ratio; CI = confidence interval; NA = not applicable; HCT-CI = hematopoietic cell transplantation–specific comorbidity index; mEBMT = modified European Society for Blood and Marrow Transplantation.