TABLE II.
Unadjusted and adjusted logistic regression models estimating the risk of advanced stage of breast cancer (I, II vs. III, IV) in women with and without metformin exposure
| Variable | Unadjusted analysis | Adjusted analysisa | ||
|---|---|---|---|---|
|
|
|
|||
| OR | 95% CI | OR | 95% CI | |
| Metformin use | 0.94 | 0.79 to 1.12 | 0.98 | 0.81 to 1.19 |
| Cumulative metformin duration | ||||
| <1 Year | 1.06 | 0.72 to 1.54 | 1.13 | 0.76 to 1.67 |
| 1 to 3 Years | 0.88 | 0.73 to 1.06 | 0.92 | 0.75 to 1.13 |
| >3 Years | 1.13 | 0.83 to 1.55 | 1.15 | 0.82 to 1.61 |
a
Model adjusted for age at breast cancer diagnosis, socioeconomic status, urban residence (yes or no), number of outpatient visits in the 2 years preceding the breast cancer diagnosis, aggregated diagnosis group weighted score, diabetes duration (years), use of other oral hypoglycemic agents (yes or no), use of insulin (yes or no), mammogram within the 3 years preceding the breast cancer diagnosis.
OR = odds ratio; CI = confidence interval.