TABLE I.
Demographic and clinical characteristics by age category
| Characteristic | Age group | p Value | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Overall | <65 Years | ≥65 Years | |||||
|
|
|
|
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| (n) | (%) | (n) | (%) | (n) | (%) | ||
| Patients | 138 | 82 | 56 | — | |||
| Male sex | 84 | 60.9 | 49 | 59.8 | 35 | 62.5 | 0.746 |
| ECOG performance status < 2 | 75 | 54.3 | 55 | 67.1 | 20 | 35.7 | <0.001 |
| Surgery | |||||||
| Biopsy | 23 | 16.7 | 9 | 11.0 | 14 | 25.0 | 0.03 |
| Resection | 115 | 83.3 | 73 | 89.0 | 42 | 75.0 | |
| Adjuvant therapy | |||||||
| Best supportive care | 10 | 7.2 | 4 | 4.9 | 6 | 10.7 | 0.001 |
| Radiotherapy alone | 39 | 28.3 | 11 | 13.4 | 28 | 50.0 | |
| Chemoradiotherapy | 81 | 58.7 | 63 | 76.8 | 18 | 32.1 | |
| Temozolomide monotherapy | 8 | 5.8 | 4 | 4.9 | 4 | 7.1 | |
| Radiotherapy fractionation | |||||||
| No radiotherapy | 18 | 13.0 | 8 | 9.8 | 10 | 17.9 | |
| Whole-brain radiotherapy | 13 | 9.4 | 3 | 3.7 | 10 | 17.9 | |
| Hypofractionated (40 Gy, 15 fr) | 41 | 29.7 | 12 | 14.6 | 29 | 51.8 | |
| Conventional (59.4–60 Gy, 30–33 fr) | 66 | 47.8 | 59 | 72.0 | 7 | 12.5 | 0.001 |
ECOG = Eastern Cooperative Oncology Group; fr = fractions.