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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Pharmacol Ther. 2017 Feb 4;173:135–145. doi: 10.1016/j.pharmthera.2017.02.012

Figure 5. Schematic representation of the thyroid hormone receptor isoforms.

Figure 5

TRs are encoded by the THRA and THRB genes, which produce multiple isoforms, Depicted are the major isoforms that modulated the actions of T3, with exception of TRalpha2 which does not bind T3 but acts as negative dominant by competing for the TRE with other TRs. TR isoforms share high sequence homology within their functional domains.