Table 1.
Association between change in maternal arterial blood pressure from the second to third trimester and the odds of small-for-gestational-age birth among 762 normotensive pregnancies in the Healthy Start study, 2009–2014.
| Unadjusted OR and 95% CI | Adjusted1 OR and 95% CI | Adjusted1 + Average 2nd trimester BP, OR and 95% CI | Adjusted1 + Predicted gestational weight gain to 39 weeks, OR and 95% CI | |
|---|---|---|---|---|
| 2nd to 3rd trimester change in diastolic BP | ||||
| Per 1 mmHg increase | 1.04 (0.99–1.09) | 1.05 (1.00–1.11) | 1.04 (0.98–1.10) | 1.06 (1.00–1.11) |
| Above median (2.9 mmHg) increase | 1.66 (1.08–2.54) | 1.86 (1.19–2.91) | 1.74 (1.09–2.78) | 1.87 (1.18–2.95) |
| Quartile 1: −9.1 to 0.3 mmHg | Ref | Ref | Ref | Ref |
| Quartile 2: 0.3 to 2.9 mmHg | 0.80 (0.41–1.53) | 0.82 (0.42–1.63) | 0.76 (0.38–1.53) | 0.79 (0.39–1.58) |
| Quartile 3: 2.9 to 5.6 mmHg | 1.26 (0.69–2.30) | 1.46 (0.78–2.73) | 1.33 (0.69–2.55) | 1.41 (0.74–2.68) |
| Quartile 4: 5.6 to 19.2 mmHg | 1.72 (0.97–3.07) | 1.95 (1.06–3.58) | 1.72 (0.89–3.31) | 1.94 (1.04–3.62) |
| 2nd to 3rd trimester change in systolic BP | ||||
| Per 1 mmHg increase | 1.03 (0.99–1.07) | 1.03 (0.99–1.07) | 1.01 (0.97–1.06) | 1.04 (1.00–1.08) |
| Above median (3.7 mmHg) increase | 1.59 (1.04–2.43) | 1.70 (1.10–2.64) | 1.48 (0.93–2.36) | 1.69 (1.08–2.65) |
| Quartile 1: −18.9 to −0.3 mmHg | Ref | Ref | Ref | Ref |
| Quartile 2: −0.2 to 3.7 mmHg | 0.94 (0.49–1.79) | 0.91 (0.47–1.76) | 0.78 (0.39–1.55) | 0.99 (0.50–1.96) |
| Quartile 3: 3.7 to 7.5 mmHg | 1.45 (0.79–2.65) | 1.64 (0.88–3.05) | 1.33 (0.69–2.56) | 1.61 (0.85–3.05) |
| Quartile 4: 7.5 to 20.5 mmHg | 1.63 (0.90–2.94) | 1.61 (0.87–2.97) | 1.26 (0.65–2.43) | 1.76 (0.94–3.31) |
1
Adjusted for maternal age, race/ethnicity, education, pre-pregnancy body mass index (kg/m2), smoking during pregnancy (any vs. none), previous pregnancies (any vs. none). Abbreviations: BP, arterial blood pressure; CI, confidence interval; OR, odds ratio