Table 2.
Association between change in maternal arterial blood pressure from the second to third trimester and neonatal body composition among 692 normotensive pregnancies in the Healthy Start study, 2009–2014.
|
|
|||
|---|---|---|---|
| Unadjusted difference and 95% CI | Adjusted1 difference and 95% CI | Adjusted1 + Predicted gestational weight gain to 39 weeks, OR and 95% CI | |
| Difference in neonatal percent fat mass (%) | |||
| Increase in diastolic BP | |||
| Per 1 mmHg | −0.10 (−0.17, −0.03) | −0.09 (−0.15, −0.02) | −0.09 (−0.15, −0.02) |
| >Median (2.9) | −0.94 (−1.52, −0.36) | −0.78 (−1.34, −0.22) | −0.75 (−1.30, −0.20) |
| Q1 (−9.1, 0.3) | Ref | Ref | Ref |
| Q2 (0.3, 2.9) | −0.12 (−0.95, 0.70) | −0.17 (−0.96, 0.61) | −0.17 (−0.95, 0.61) |
| Q3 (2.9, 5.6) | −0.85 (−1.67, −0.03) | −0.67 (−1.46, 0.12) | −0.66 (−1.44, 0.12) |
| Q4 (5.6, 19.2) | −1.15 (−1.97, −0.33) | −1.07 (−1.86, −0.27) | −1.02 (−1.81, −0.24) |
| Increase in systolic BP | |||
| Per 1 mmHg | −0.04 (−0.09, 0.01) | −0.03 (−0.08, 0.02) | −0.03 (−0.08, 0.01) |
| > Median (3.7) | −0.46 (−1.04, 0.13) | −0.41 (−0.97, 0.14) | −0.35 (−0.90, 0.20) |
| Q1 (−18.9, −0.3) | Ref | Ref | Ref |
| Q2 (−0.2, 3.7) | 0.26 (−0.57, 1.09) | 0.44 (−0.35, 1.23) | 0.43 (−0.35, 1.21) |
| Q3: (3.7, 7.5) | −0.24 (−1.07, 0.59) | −0.13 (−0.93, 0.66) | −0.01 (−0.80, 0.77) |
| Q4: (7.5, 20.5) | −0.40 (−1.23, 0.42) | −0.24 (−1.03, 0.55) | −0.23 (−1.01, 0.55) |
| Difference in neonatal fat mass (g) | |||
| Increase in diastolic BP | |||
| Per 1 mmHg | −3.5 (−6.2, −0.9) | −3.5 (−6.1, −1.0) | −3.5 (−6.0, −1.0) |
| >Median (2.9) | −37.7 (−60.1, −15.3) | −33.0 (−54.3, −11.6) | −31.9 (−52.8, −10.9) |
| Q1 (−9.1, 0.3) | Ref | Ref | Ref |
| Q2 (0.3, 2.9) | 0.8 (−31.1, 32.6) | −5.8 (−35.9, 24.3) | −5.7 (−35.2, 23.8) |
| Q3 (2.9, 5.6) | −29.5 (−61.3, 2.2) | −25.9 (−56.0, 4.3) | −25.7 (−55.2, 3.9) |
| Q4 (5.6, 19.2) | −45.1 (−76.8, −13.3) | −46.2 (−76.5, −15.8) | −44.1 (−73.8, −14.4) |
| Increase in systolic BP | |||
| Per 1 mmHg | −1.4 (−3.3, 0.6) | −0.9 (−2.8, 0.9) | −1.0 (−2.8, 0.8) |
| > Median (3.7) | −13.9 (−36.4, 8.7) | −13.7 (−34.9, 7.6) | −10.7 (−31.5, 10.1) |
| Q1 (−18.9, −0.3) | Ref | Ref | Ref |
| Q2 (−0.2, 3.7) | 13.3 (−18.8, 45.5) | 19.5 (−10.7, 49.8) | 19.1 (−10.5, 48.7) |
| Q3: (3.7, 7.5) | −0.4 (−32.6, 31.7) | −1.2 (−31.6, 29.1) | 4.1 (−25.7, 33.9) |
| Q4: (7.5, 20.5) | −13.6 (45.5, 18.4) | −6.1 (−36.3, 24.2) | −5.8 (−35.4, 23.8) |
| Difference in neonatal fat-free mass (g) | |||
| Increase in diastolic BP | |||
| Per 1 mmHg | −0.4 (−6.2, 5.4) | −4.6 (−9.5, 0.3) | −4.5 (−9.4, 0.2) |
| >Median (2.9) | −45.9 (−95.3, 3.5) | −59.0 (−100.1, −18.0) | −57.2 (−97.6, −16.8) |
| Q1 (−9.1, 0.3) | Ref | Ref | Ref |
| Q2 (0.3, 2.9) | 66.5 (−3.6, 136.5) | 17.4 (−40.4, 75.2) | 17.6 (−39.4, 74.5) |
| Q3 (2.9, 5.6) | 1.7 (−68.1, 71.6) | −28.6 (−86.5, 29.4) | −28.2 (−85.3, 28.8) |
| Q4 (5.6, 19.2) | −26.8 (−96.5, 43.0) | −72.2 (−130.4, −13.9) | −68.7 (−126.1, −11.4) |
| Increase in systolic BP | |||
| Per 1 mmHg | 0.2 (−4.1, 4.6) | 0.4 (−3.1, 4.0) | 0.4 (−3.2, 3.9) |
| > Median (3.7) | 19.1 (−30.4, 68.6) | 4.4 (−36.4, 45.2) | 9.5 (−30.8, 49.7) |
| Q1 (−18.9, −0.3) | Ref | Ref | Ref |
| Q2 (−0.2, 3.7) | 21.3 (−48.9, 91.4) | 17.1 (−41.1, 75.2) | 16.4 (−40.8, 73.6) |
| Q3: (3.7, 7.5) | 74.8 (4.5, 145.1) | 23.9 (−34.5, 82.3) | 33.1 (−24.5, 90.7) |
| Q4: (7.5, 20.5) | −13.9 (−83.8, 56.0) | 2.7 (−55.4, 60.8) | 3.1 (−54.0, 60.2) |
1
Adjusted for gestational age at birth (days), infant sex, maternal age, race/ethnicity, education, pre-pregnancy body mass index (kg/m2), smoking during pregnancy (any vs. none), previous pregnancies (any vs. none). Abbreviations: BP, blood pressure; CI, confidence interval; Q1, first quartile; Q2, second quartile; Q3, third quartile; Q4, fourth quartile; Ref, reference level of categorical variable.