Table 2.
Patient Demographics, Tumor Clinicopathologic Features and Genetic Characteristics of Patients with Circulating Tumor Cells based upon staining with cytokeratin, CD133 and CD44.
| Variable | PanCK positive, CD133 positive, CD44 positive CTCs (n=34) | Absence of triple positive CTCs (n=26) | P-Value |
|---|---|---|---|
|
| |||
| Average Age (years) | 63.4 (27–83) | 66.3 (45–88) | 0.35 |
|
| |||
| Gender | 0.12 | ||
|
|
|||
| Male | 24 (71%) | 13 (50%) | |
|
|
|||
| Female | 10 (29%) | 13 (50%) | |
|
| |||
| Average CA19-9 | 896 (0.6–9032) | 219 (1–1031) | 0.11 |
|
| |||
| CA 19-9 Level (n=46) | 0.37 | ||
|
|
|||
| High (> 36) | 17 (68%) | 11 (52%) | |
|
|
|||
| Low (< 36) | 8 (32%) | 10 (48%) | |
|
| |||
| Surgical Resection | 0.90 | ||
|
|
|||
| Whipple | 26 (76%) | 18 (69%) | |
|
|
|||
| Distal pancreatectomy | 6 (18%) | 6 (23%) | |
|
|
|||
| Total pancreatectomy | 2 (6%) | 2 (8%) | |
|
| |||
| Average Tumor Size (cm) | 3.4 (1.8) | 2.9 (1.5) | 0.26 |
|
| |||
| Tumor Grade | 0.76 | ||
|
|
|||
| Well | 1 (3%) | 2 (8%) | |
|
|
|||
| Moderate | 18 (55%) | 13 (50%) | |
|
|
|||
| Poor | 14 (42%) | 11 (42%) | |
|
|
|||
| Not specified | |||
|
| |||
| Positive lymph nodes | 26 (76%) | 16 (62%) | 0.26 |
|
| |||
| Positive margin | 9 (26%) | 3 (12%) | 0.20 |
|
| |||
| Stage | 0.08 | ||
|
|
|||
| Stage I | 4 (12%) | 8 (31%) | |
|
|
|||
| Stage II | 29 (85%) | 17 (65%) | |
|
|
|||
| Stage III | 0 (0%) | 1 (4%) | |
|
|
|||
| Stage IV | 1 (3%) | 0 (0%) | |
|
| |||
| Perineural invasion | 28 (82%) | 19 (73%) | 0.53 |
|
| |||
| Perivascular invasion | 26 (76%) | 14 (54%) | 0.10 |
|
| |||
| Neoadjuvant Chemotherapy | 13 (38%) | 11 (42%) | 0.80 |
|
| |||
| Adjuvant Chemotherapy (n=57) | 30 (91%) | 22 (92%) | > 0.99 |