Table 3.
Patient Demographics, Tumor Clinicopathologic Features and Genetic Characteristics of Patients with Circulating Tumor Cells based upon staining with cytokeratin and CD133.
| Variable | PanCK positive, CD133 positive, CD44 negative CTCs (n=40) | Absence of PanCK positive, CD133 positive, CD44 negative CTCs (n=20) | P-Value |
|---|---|---|---|
|
| |||
| Average Age (years) | 65 (27–85) | 64 (40–88) | 0.76 |
|
| |||
| Gender | 0.26 | ||
|
|
|||
| Male | 27 (68%) | 10 (50%) | |
|
|
|||
| Female | 13 (32%) | 10 (50%) | |
|
| |||
| Average CA19-9 | 483 (0.6–3758) | 946 (1–9032) | 0.55 |
|
| |||
| CA 19-9 Level (n=46) | 0.35 | ||
|
|
|||
| High (> 36) | 21 (66%) | 7 (50%) | |
|
|
|||
| Low (< 36) | 11 (34%) | 7 (50%) | |
|
| |||
| Surgical Resection | 0.64 | ||
|
|
|||
| Whipple | 29 (73%) | 15 (75%) | |
|
|
|||
| Distal pancreatectomy | 9 (22%) | 3 (15%) | |
|
|
|||
| Total pancreatectomy | 2 (5%) | 2 (10%) | |
|
| |||
| Average Tumor Size (cm) | 3.2 (1.7) | 3.3 (1.7) | 0.81 |
|
| |||
| Tumor Grade | 0.90 | ||
|
|
|||
| Well | 2 (5%) | 1 (5%) | |
|
|
|||
| Moderate | 21 (54%) | 10 (50%) | |
|
|
|||
| Poor | 16 (41%) | 9 (45%) | |
|
|
|||
| Not specified | |||
|
| |||
| Positive lymph nodes | 28 (70%) | 14 (70%) | >0.99 |
|
| |||
| Positive margin | 8 (20%) | 4 (20%) | >0.99 |
|
| |||
| Stage | 0.69 | ||
|
|
|||
| Stage I | 8 (20%) | 4 (20%) | |
|
|
|||
| Stage II | 31 (78%) | 15 (75%) | |
|
|
|||
| Stage III | 0 (0%) | 1 (5%) | |
|
|
|||
| Stage IV | 1 (2%) | 0 (0%) | |
|
| |||
| Perineural invasion | 31 (78%) | 16 (80%) | 0.99 |
|
| |||
| Perivascular invasion | 27 (68%) | 13 (65%) | 0.99 |
|
| |||
| Neoadjuvant Chemotherapy | 15 (38%) | 9 (45%) | 0.59 |
|
| |||
| Adjuvant Chemotherapy | 35 (88%) | 17 (100%) | 0.31 |