Table 4.
Cumulative incidence of tumor recurrence accounting for death as a competing risk, with hazard ratio adjusted for patient age and gender
| Variable | Hazard Ratio | 95% Confidence Interval | p-value |
|---|---|---|---|
|
| |||
| ALDH-positive CTC | 3.4 | 1.16, 9.76 | 0.03 |
|
| |||
| Number of cells: ALDH positive CTC | 1.00 | 0.94, 1.06 | 0.93 |
|
| |||
| Cytokeratin-positive only CTC | 0.8 | 0.32, 2 | 0.64 |
|
| |||
| Number of cells: PanCK+ only | 1.18 | 0.83, 1.68 | 0.36 |
|
| |||
| Triple Positive (cytokeratin, CD133, CD44) CTC | 6.45 | 2.12, 19.65 | < 0.01 |
|
| |||
| Number of cells: Triple positive | 1.76 | 1.16, 2.65 | 0.01 |
|
| |||
| Cytokeratin-positive, CD133 positive CTC | 3.24 | 1.22, 8.62 | 0.02 |
|
| |||
| Number of cells: PanCK+/CD133+ | 0.98 | 0.78, 1.21 | 0.83 |
|
| |||
| Positive Lymph Nodes | 3.4 | 1.15, 10.0 | 0.03 |
|
| |||
| Perivascular Invasion | 2.33 | 0.98, 5.56 | 0.06 |
|
| |||
| ALDH Stain | |||
|
| |||
| Weak | Ref | Ref | Ref |
|
|
|||
| Moderate | 1.01 | 0.45, 2.28 | 0.98 |
|
|
|||
| Strong | 0.997 | 0.35, 2.7 | 0.96 |
|
| |||
| ALDH as intense as controls | 0.69 | 0.3, 1.59 | 0.39 |
|
| |||
| Total bilirubin level | 1.33 | ||
|
| |||
| Positive Margin | 1.6 | 0.65, 3.97 | 0.31 |
|
| |||
| Tumor Grade | |||
|
| |||
| Well/Moderate | Ref | Ref | Ref |
|
|
|||
| Poor | 1.5 | 0.72, 3.3 | 0.27 |
|
| |||
| Perineural Invasion | 2.6 | 0.9, 7.6 | 0.08 |
|
| |||
| Tumor > 3 cm | 1.5 | 0.69, 3.22 | 0.31 |
|
| |||
| Neoadjuvant Chemo | 1.6 | 0.74, 3.4 | 0.23 |
|
| |||
| Adjuvant Chemo | 1.58 | 0.24, 10.55 | 0.63 |