Table 5.

Factors associated with Overall Survival by Cox-Mantel Analysis, adjusted for patient gender and age

Survival Factor	Median OS (months)	Hazard Ratio (HR)	95% Confidence Interval	p-value
PanCK+/ALDH+ CTCs
Present	17.5	--	--	0.004
Absent	NR
Number of cells: ALDH+		0.98	0.94, 1.02	0.29
PanCK+ only CTC
Present	16.2	1.4	0.48, 3.99	0.34
Absent	22.8
Number of cells: PanCK+ only		0.94	0.72, 1.23	0.66
PanCK+/CD133+/ CD44+ CTC
Present	16.3	--	--	<0.0001
Absent	NR
Number of cells: Triple positive		1.51	1.07, 2.13	0.02
PanCK+/CD133+/ CD44- CTC
Present	17.5	4.3	0.55, 33.6	0.055
Absent	NR
Number of cells: PanCK+/CD133+		0.97	0.87, 1.08	0.60
ALDH intensity compared to controls
Yes	22.8	0.51	0.16, 1.59	0.80
No	20.2
ALDH overall stain
Weak	NR	Ref	--	0.62
Moderate	16.4	0.96	0.32, 2.84
Strong	22.8	0.34	0.04, 2.92
CA19-9
≥ 36 U/ml	20.1	1.83	0.5, 6.74	0.24
< 36 U/ml	NR
Tumor Size
≥ 3 cm	20.1	1.74	0.59, 5.17	0.33
< 3 cm	17.5
Positive LN
Yes	17.5	2.5	0.53, 11.76	0.28
No	NR
Positive Margin
Yes	10.4	5.4	1.63, 17.94	0.002
No	NR
Tumor Grade
Well/Moderate	NR	1.9	0.64, 5.9	0.38
Poor	16.3
Tumor Stage
Stage I	NR	4.0	0.5, 32.7	0.39
Stage II to IV	17.5
Perineural invasion
Yes	20.2	2.4	0.5, 11.2	0.49
No	NR
Perivascular invasion
Yes	17.5	8.1	1.06, 62.2	0.01
No	NR
Neoadjuvant chemotherapy
Yes	16.4	0.87	0.3, 2.56	0.63
No	20.2
Adjuvant chemotherapy
Yes	20.2	0.84	0.17, 4.3	0.59
No	NR