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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Pharmacol Ther. 2017 Feb 7;173:159–170. doi: 10.1016/j.pharmthera.2017.02.014

Figure 3. Peptides targeting the substrate-binding site.

Figure 3

Constrained peptides mimicking peptide substrates can be designed to occlude the substrate-binding groove, thereby inhibiting substrate phosphorylation for a kinase of interest. Successfully targeted kinases using this strategy include c-Src, Abl, Akt and CDK2.