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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Pharmacol Ther. 2017 Feb 7;173:159–170. doi: 10.1016/j.pharmthera.2017.02.014

Figure 5. Disruption of protein-protein interactions involving kinases.

Figure 5

A) Spatiotemporal regulation of kinases can be disrupted by blocking PPI interfaces between kinases and adaptor proteins. Illustrated in this example is the inhibited interaction between PKA and AKAP proteins to disrupt compartmentalized signaling. B) SH2 or SH3 domains can also be selectively targeted using peptide-based compounds to block localized signaling interactions with kinases. C) Some kinases have defined protein interactions that are distinct from the substrate-binding site such as the RH domain of GRK5 and 6, the polo-box domain of Plk1 or the helical domain of PI3K. These unique interaction sites can be selectively targeted for peptide-based inhibition.